Bryan Bryson

Research Description

Mycobacterium tuberculosis is one of human history’s most challenging pathogens. We lack a protective TB vaccine capable of altering the trajectory of the pandemic. We believe that progress to a protective vaccine is hampered by an incomplete understanding of how the human immune system controls infection. Our research group seeks to take an engineering approach to address the knowledge gaps that persist in our understanding of Mtb-host interactions. We develop quantitative biochemical approaches to address what we call “infection black boxes.” Some recent examples of approaches we have developed to address these black boxes include quantification of Mtb-derived antigen presentation on MHC-I and MHC-II, identifying the outer membrane proteome of Mtb, and developing new technologies to map the composition of the phagosome. We are excited to now translate these basic biochemical discoveries into translational products.